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Taken together, such evidence strengthens the argument that tirzepatide should carry an explicit warning for bowel obstruction as a potential adverse effect, particularly given its increasing use in diabetes and obesity management

Data sources We retrieved data from Danish nationwide registries including the Danish Cancer Registry [17], the Danish National Prescription Registry [18], the Danish National Patient Registry [19], the Danish Civil Registration System [20], the Danish Pathology Register [21] and socioeconomic registries at Statistics Denmark [22, 23]

Weight reduction by sibutramine in obese subjects in primary care medicine: the SAT Study

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While the injection, Zepbound, is well-studied and shown to be effective, oral tirzepatide is limited to compounded forms without FDA approval