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Obesity is characterized by chronic low-grade systemic inflammation, with elevated levels of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and C-reactive protein

Both medications include tirzepatide as a dual GIP and GLP-1 receptor agonist, aiding blood sugar regulation and appetite control

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These observations are consistent with clinical findings that side effects of GLP-1 receptor agonists often attenuate over time (Wharton et al