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Large-scale pharmacoepidemiological data has not demonstrated a statistically significant increase in suicidal behaviour but there are important signals in specific subgroups, particularly those already on antidepressants or benzodiazepines

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Most (83.5%) patients treated with semaglutide 2.4 mg reached the maximum dose (2.4 mg), while 25.9% of patients treated with tirzepatide reached the maximum dose (15 mg)