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More significantly, RA patients already on DMARDs (disease-modifying antirheumatic drugs) who added a GLP-1 agonist had fewer disease flares than those on DMARDs alone

The GLP-1 RA are still under prescribed in developed and well-funded health care systems and are not even available in the most modern formulations in some parts of the world

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1 The discovery of non-peptidic drugs has been hampered for many years, primarily owing to the difficulty of mimicking the peptidereceptor interactions with small molecule non-peptidic agonists