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Sitagliptin, the first approved DPP-4 inhibitor, was developed by a group led by Nancy Thornberry and Ann Weber at Merck and lowered HbA1c by ~0.8% as a monotherapy with a highly significant reduction of ~1.9% when icombined with metformin (1)

However, compared to other weight loss methods, Semaglutide GLP-1 tends to show results fairly quickly

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