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Description

The hormonal benefits follow the trajectory of weight loss: Weeks 1-8: Weight loss begins

Systemic GLP-1 receptor deficiency impairs GLP-1-induced anorexia as anticipated.41 However, these mice do not display alterations in baseline body weight, suggesting that GLP-1 receptor is not critical for body weight regulation under basal conditions.41 Notably, subsequent investigations revealed that both male and female mice lacking systemic GLP-1 receptor are resistant to diet-induced obesity.39,42 Focusing on central mechanisms, intracerebroventricular administration of GLP-1 failed to modulate feeding behavior in GLP-1 receptor global knockout mice.41 Central inhibition of GLP-1 receptor disrupts glucose homeostasis and reduces food intake, whereas peripheral GLP-1 receptor inactivation impairs glucose-stimulated insulin secretion, diminishes glucose clearance, elevates glucagon levels, and accelerates gastric emptying

Lifestyle changes (nutrition, exercise, sleep) developed during treatment significantly support long-term success.

Cohort definition We selected two groups of patients: (1) those who initiated any SGLT2i (dapagliflozin, empagliflozin, canagliflozin, ertugliflozin) between 1 January 2015 and 30 September 2020