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Overall, serious side effects, such as suicidal ideations are very rare. I find the reduction in inflammation most compelling

Enhanced ductal replication under these circumstances may simply lead to pancreas growth as observed by Koehler et al

Gastrointestinal and Pancreatic Safety Concerns Gastrointestinal adverse effects are the most commonly reported side effects of GLP-1RAs

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These medications reduce hyperglycemia (Hb1Ac reduction of 0.8 1.4%) through the inhibition of glucose reabsorption in the proximal convoluted tubule of the kidney and the resulting increase in glycosuria ( In light of this evidence, these therapies have opened a new paradigm not only for the management of altered glucose metabolism in T2D but also in consideration of their pleiotropic effects (31), as well as the impact on the function of different organs such as the brain (32), heart (32, 33) and pancreas ( Emerging data indicate that the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis may play a role in either mediating the metabolic and neuroendocrine effect of these drugs or responding to the profound body modifications fostered by GLP-1RAs and SGLT-2is