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But if you're a high-performing executive, you don't need a drug to suppress your appetite

Cryo-EM analysis of a complex involving an exendin-4 analogue, the GLP-1R and Gs protein revealed two receptor conformers with distinct modes of peptide-receptor engagement

We delineate how systemic metabolic dysfunction, often associated with obesity, synergizes with local inflammation to alter the balance between MMPs and their tissue inhibitors TIMPs, thus contributing to a perpetuating circle of inflammation and fibrosis

In conclusion, this review indicates that the effects on HR differ within the class of GLP-1 RAs: short-acting GLP-1 RAs are associated with a modest and transient HR increase before returning to baseline levels, while some long-acting GLP-1 RAs are associated with a more pronounced and sustained increase during the day and night

Dr Paula Diab, a a diabetologist, gives an overview of GLP-1 drugs, their approved uses, and who might benefit the most.