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Among participants with overweight or obesity but without diabetes (Jastreboff et al .), 72% reverted to normoglycaemia by week 48

and intensified cheese-like odor, due to the production of higher quantities of volatile fatty acids

[6] People with certain conditions such as significant lipodystrophy or a history of skin reactions to injectable medications may require additional clinical input before beginning treatment

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In patients with type 2 diabetes, semaglutide is reported to improve glycaemic control dose-dependently, decreasing HbA 1c levels by 1.7% (18.7 mmol/mol) vs 0.5% (5.5 mmol/mol) with placebo and 4.8 kg of weight loss vs 1.2 kg with placebo, relative to baseline