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This means your travel case needs to maintain actual refrigerator temperatures, not just "below 86 degrees." A FRIO wallet alone is insufficient

Pratley RE, Kang J, Trautmann ME, Hompesch M, Han O, Stewart J, et al

Signs of an allergic (hypersensitivity) reaction, including rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing

The vials should be stored upright in their original containers, protected from light and kept away from the freezer compartment (freezing should be avoided as it may compromise the solution)
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