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"Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial." December 11, 2025

Many providers recommend an 80/20 approach, focusing on high-quality protein and nutrient-dense foods

For those managing diabetes or seeking weight loss options, Wegovy or metformin may be potential options

If phase III trials confirm its promise, retatrutide could reshape the landscape of obesity treatment and bring new hope to millions of people worldwide

However, given the observational nature of the study and the potential for residual confounding, these findings should be interpreted with caution and do not definitively establish a detrimental biological effect