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Diabetes-related thrombotic risk factors include: Hyperglycaemia-induced endothelial dysfunction , promoting a prothrombotic state Increased platelet reactivity and aggregation Elevated levels of clotting factors including fibrinogen and von Willebrand factor Chronic inflammation with raised inflammatory markers Impaired fibrinolysis , reducing the body's ability to break down clots Obesity independently increases thrombotic risk through multiple mechanisms

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Pharmacokinetics (Coskun et al., Cell Metabolism 2022) Phase 1 PK data established the ~6-day half-life and once-weekly dosing rationale

Hormonal causes * Low testosterone (hypogonadism) * Thyroid disorders * High prolactin levels 4

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