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Of these, 17.8% (n = 21) switched to semaglutide during the study period

Additionally, parenteral GLP-1 treatments have strong clinical validation, which increases physician confidence and patient adherence, further driving market dominance

This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors

The gut microbiota, often referred to as a forgotten organ, is now acknowledged as playing a fundamental role in host physiology, including the regulation of the immune response, synthesis of vitamins, development of the gut barrier, and production of bioactive metabolites [13], as well as regulating dietary energy extraction, fat storage, and insulin sensitivity [14]

Marchese A, Paing MM, Temple BR, Trejo J