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Our understanding was that drugs of abuse hijacked parts of the brain

The appeal with GLP-1 is that it cut the pressure and cut the weight
Furthermore, the degree to which various exogenous GLP1-RAs penetrate the bloodbrain barrier (BBB) and access central receptors remains unresolved and an ongoing area of research
Effect of weight loss on cardiometabolic risk: observational analysis of two randomised controlled trials of community weight-loss programmes

Available from: Han SH, Safeek R, Ockerman K, Trieu N, Mars P, Klenke A, et al (2023) Public interest in the off-label use of glucagon-like peptide 1 agonists (Ozempic) for cosmetic weight loss: a Google trends analysis
