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This 39-amino acid peptide showed structural similarity to human GLP-1, sharing approximately 53% sequence homology

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Dunlay SM, Roger VL, Redfield MM

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Patients without confirmed deficiency but with risk factors may benefit from prophylactic oral B12 supplementation (typically 50150 micrograms daily), though this should be discussed with their healthcare provider rather than self-initiated

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Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]

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