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[29] Combination drugs [edit] Some DPP-4 inhibitor drugs have received approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production
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In mice, NNC00902764 demonstrates superior body weight reduction relative to pharmacokinetically-matched GLP-1R monoagonism and this difference was lost with ablation of CNS-GIPR expression 54

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