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In late 2025, orforglipron received a Commissioners National Priority Voucher, enabling an accelerated FDA review

Vomiting was also more frequent among treated patients, but again, the majority of cases were considered mild and did not require hospitalisation or additional medical treatment

14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

confirmed growth hormone deficiency should be assessed and treated via NHS endocrinology pathways

Evidence suggests that women with UFs have increased angiogenesis and that angiogenic growth factors such as VEGF and PDGF are involved in the abnormal vasculature formation and other features of UF pathophysiology (Figure 3