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Dose increases should only happen when nausea is mild or has mostly resolved

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The SURMOUNT-5 clinical trial published in The New England Journal of Medicine showed that Zepbound (tirzepatide) achieved an average weight loss of 20.2% compared to 13.7% with Wegovy (semaglutide) at 72 weeks

Targeting inflammatory pathways, specifically the NLR family pyrin domain containing 3 (NLRP3)/IL-1/IL6/C-reactive protein (CRP) pathway, has emerged as another strategy for improving cardiorenal outcomes in high-risk populations