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These recommendations are based on results that showed that GLP-1RA compared with insulin therapy (basal, premixed, or intensified basal-bolus regimens) have similar or even better efficacy in HbA1c reduction and a lower hypoglycemia risk, promotes weight loss instead of weight gain, and reduces the burden of drug administration frequency and self-monitoring of blood glucose [1, 2]

The absorbance of the released p- nitroanilide was measured every 2 min over 4 h at 405 nm using a Thermo Scientific Multiskan Ascent microplate reader

This hepatic insulin resistance increases gluconeogenesis, leading to elevated glucose and insulin levels [17]