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Both are observational, the ACR one is a conference abstract, and at least one database study has flagged a possible short-term rise in new-onset RA early in therapy

The new study, published in Nature Health, covers more than half a decade of posts from nearly 70,000 Reddit users and highlights two main classes of symptoms that warrant further study: reproductive symptoms, including irregular menstrual cycles, and temperature-related complaints, such as chills and hot flashes