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in clinical studies, an increase in hypoglycemia incidence was only observed in tirzepatide-treated patients if they had a comedication with insulin and/or oral insulinotropic agents (sulfonylurea) (61)

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Based on data from the phase 2 clinical trial of retatrutide (NCT04881760), published in the New England Journal of Medicine in 2023, gastrointestinal adverse events were among the most frequently reported side effects across all dose groups

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