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Both prevent sharp increases in blood sugar, but while metformin reduces absorption of glucose in the small intestine, insulin removes glucose once it enters the blood

Emerging evidence suggests that those patients living with insulin resistance or obesity may derive greater clinical benefit, highlighting the importance of a phenotype-based treatment approach

This small addition makes a world of difference

A 2024 retrospective study found that GLP-1-treated patients with inflammatory bowel disease in remission tolerated semaglutide without disease flares, while those with active inflammation experienced variable symptom changes

"But the real secret to longevity is eating right, exercising, sleeping, dealing with the stress of your life, finding some purpose in your existence [and] realizing you have agency over the future." "These are things that your mom would have told you [and that] you don't need a doctor to be emphasizing." While GLP-1s may not be a fix-all, combining these medications with foundational health practices "makes a lot of sense," Oz said