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Defined as an out-pocketing of colon wall - most common location is the sigmoid colon Diverticulosis: Painless rectal bleeding Diverticulitis:Presents with constipation

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The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which respectively define the peripheral and central GLP-1 systems

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