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First 3-6 months: close monitoring phase The dose-escalation period is when most side effects emerge and when your body adjusts to the medication

When you reduce your calorie intake (especially from carbohydrates), your body taps into its glycogen stores for energy

This calculator accounts for your specific concentration and gives you a precise number to draw to

However, more participants discontinued treatment with tirzepatide 10 mg (OR 2.39 [95% CI 1.02, 5.59], I 2 0%) and 15 mg (OR 3.64 [95% CI 1.51, 8.78], I 2 13%) when compared with placebo (ESM Table 3)

skipping meals risks nutrient deficiencies and energy crashes without additional benefit