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Scheen AJ, Lefebvre PJ (2023) Glucagon, from past to present: a century of intensive research and controversies

Many people find that using targeted supplements can help bridge the gap during these transitions

GLP-1 medications work partly by suppressing appetite and slowing gastric emptying. That's the mechanism behind the weight loss. But less food in means fewer vitamins and minerals in and the research now shows this isn't a theoretical concern. Urbina et al. (2026) found that across 480,825 GLP-1 users, 22% had a new nutritional deficiency diagnosis by 12 months. Vitamin D was most common (13.6%), followed by nutritional anemia (4%), iron deficiency (3.2%), and B vitamin deficiency (2.6%). In a smaller dietary study (Johnson et al. 2025, Frontiers in Nutrition), 64% of GLP-1 users didn't meet iron intake recommendations, and 72% fell short on calcium.* This GLP-1 supplement covers the five most at-risk nutrients with bioavailable forms: methylcobalamin B12, chelated iron, chelated zinc, 5-MTHF folate, and vitamin D3

Additionally, it showed further improvement in lipid parameters in patients already on secondary prevention

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