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Description
During follow-up from year six to year 15, the average weight loss relative to baseline that was maintained in 6.2% of metformin users, 3.7% of lifestyle intervention participants, and 2.8% of placebo recipients
Ozempic and Mounjaro, although not approved specifically for weight loss but rather for the treatment of diabetes, have been widely prescribed off-label due to their weight loss side effects

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Some people do combine them, and there is no known dangerous interaction

People on GLP-1 drugs frequently report fatigue and muscle loss as the weight drops
