how often glp 1 injections GLP-1 drugs, even when they fail, are giving researchers new insight about obesity : NPR Who Should Explore GLP-1 Shots

Yes when medically supervised, GLP-1s are considered safe for ongoing use

doi: 10.1016/s0196-9781(02)00280-2 55 LutzTADel PreteESzabadyMMScharrerE

Alternatively, to extend the half-life of endogenous GLP-1, DPP-4 inhibitors are prescribed

In homozygous human FcRn Tg32 mice, groups of female and male mice (816 weeks, 21.530.0 g, 5 mice/23 cages/group) were given either IV or SC injection, into the scruff of the neck, of 4 mg/kg of GLP-1 albumin fusions, diluted in DPBS (pH 7.4) (Sigma-Aldrich), respectively

Within this era, innovation emerges in the form of longer-acting injectables, moving beyond weekly injections towards monthly and longer dosing intervals, adding a new approach to the maintenance-focused paradigm