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Genetics, lifestyle, hormonal balance, and gut microbiota may influence how well a person responds

Open 6 , e2329178 (2023)

For gastrointestinal symptoms commonly associated with GLP-1 therapy, research on specific strains (though not in GLP-1 users specifically) includes: Lactobacillus rhamnosus GG (ATCC 53103) has evidence for diarrhoea management Bifidobacterium lactis BB-12 and Bifidobacterium longum BB536 have been studied for constipation relief Lactobacillus plantarum 299v has some evidence for bloating and abdominal discomfort Colony-forming units (CFUs) indicate the number of viable bacteria per dose

Taken together, our data support the hypothesis that dysregulation of serotonin metabolism, with reduction in fasting levels and increased meal-stimulated levels, may contribute to excessive prandial insulin secretion and hypoglycemia in patients with PBH

Close monitoring of blood sugar is essential, particularly if you frequently feel tired, to allow for timely adjustments to medication or diet