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Recent clinical observations suggest GLP-1 receptor agonists may influence anxiety symptoms through multiple biological pathways

Interestingly, glucagon-like peptide-1 receptor agonists (GLP-1RAs), used in the treatment of T2DM and obesity, are known to show pro-cognitive and neuroprotective properties, and exert modulatory effects on immune, endocrine and metabolic processes in the central nervous system

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Efficacy and safety data were sourced from the STEP trials (Body Mass Index, systolic blood pressure and glycemic status) from a cohort of adults aged on average 48 years with obesity (BMI30 kg/m2) and 1 obesity-related comorbidities, over a time horizon of 40 years