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Do not adjust your dose without the guidance of your healthcare provider

Seek medical review if you experience severe cold intolerance affecting daily life, cold sensitivity with dizziness or palpitations, rapid weight loss exceeding 0.5-1 kg weekly, or symptoms suggesting thyroid problems such as extreme fatigue, persistent constipation, or hair loss

In research settings this pathway triad is studied for effects on appetite signals, gastric emptying, insulin dynamics, and energy expenditure

1 On April 24, 2025 , a federal court denied the Outsourcing Facilities Association's preliminary-injunction motion, letting the FDA's timeline stand

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