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The mechanism of action of these drugs, in simple terms, is that they mimic natural gut hormones (such as GLP-1, and in the case of tirzepatide, also GIP) which regulate appetite and satiety

Because excess weight is closely linked to insulin resistance, fatty liver disease, sleep apnoea, cardiovascular disease, and progression to type 2 diabetes, weight loss achieved with GLP-1 therapy can have wide-ranging metabolic benefits even before diabetes develops

Multilevel here indicates that peaks are nested within studies

Dehydration and blood sugar fluctuations are the usual culprits

Both approaches are effective, but they work in completely different ways and are better suited for different people GLP-1 medications mimic a hormone your body naturally makes