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Chronic systemic inflammation can contribute to concerns such as: Acne flare-ups Redness and irritation Slower skin healing Premature skin aging By improving metabolic health and reducing inflammatory signaling, some individuals notice calmer skin tone, improved clarity, and healthier overall skin appearance

Two legitimate routes exist: enrolling in an active TRIUMPH Phase 3 clinical trial at a participating site (free, medically supervised, pharmaceutical-grade), or a prescription for compounded retatrutide via a licensed 503A pharmacy (not FDA-approved, quality varies by compounder)

The combination of these effects could provide meaningful metabolic support even if GLP-1 increases remain minimal

doi: 10.1002/oby.22054

TD Cowen analyst Steve Scala has flagged the high rate of discontinuation as a concern and suggested it could make outcomes of future trials harder to predict