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101 However, considering the previous positive findings with exenatide in the same PD model, differences in dosing regimen could be the main cause of failure rather than the drug characteristic itself

The intranasal administration of peptides for treating a disorders originating in the brain is not a novel concept, but only the vasopressin analog desmopressin has been used clinically by this route for several decades to treat diabetes insipidus (Kastin and Pan, 2006)

The discontinuation rates due to adverse events, which were comparable to placebo, suggest that the transition to oral orforglipron is generally well-tolerated by patients already acclimated to incretin therapy