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1, left panel), this halogenation was not essential to its biological activity since the non-halogenated indole JWU-A016 also exerted a dose-dependent stimulatory effect to raise the [Ca 2+ ] i (Fig

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In the pursuit of innovative therapeutic strategies, by pharmacologically targeting the HBP/EIF3H/YAP axis, we demonstrate the feasibility of reactivating the degradation process of YAP, thereby enhancing the potency of chemotherapeutic agents and impeding tumor progression

That feature makes it uniquely useful when drug development generates improvements that are intertwined with the original invention and cannot be claimed effectively in a standalone application