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Description
These medications all work through the same basic mechanism of activating GLP-1 receptors

There is no contraindication between tirzepatide and PDE-5 inhibitors
Aulinger, B
Since mood disorders in PCOS are closely linked to hormonal imbalances, inflammation, and metabolic stress, these medications may provide greater psychological relief for this group compared to others

This shift happens because tirzepatide activates GIP and GLP-1 receptors that slow gastric emptying and enhance satiety signals