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In addition, they showed that the 5-hydroxytryptamine 2A (5-HT 2A ) receptor is crucial for GLP-1RA-induced weight loss after exendin-4 ICV injection, such as peripheral injection of liraglutide in rats

For long-term success, they should be combined with: Nutrition counseling to support a sustainable dietary pattern Exercise and physical therapy to strengthen the back and core Behavioral coaching to build lasting habits Additionally, patients should avoid the temptation of using GLP-1 medications as a quick fix or without medical supervision

In addition to delaying gastric emptying, GLP-1RAs exert direct effects on the central nervous system to suppress appetite and promote weight loss [9, 11]

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Tracking Intake and Accountability Using food diary or macro tracking apps increases awareness of hidden calories and macronutrient balance