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Theres an entire demographic that can benefit from the pills, said Dr Fatima Cody Stanford, a Massachusetts General Hospital obesity expert

Pioglitazone has its place in medical history for helping those with severe insulin resistance, but for many on a weight loss journey, the GLP-1 class offers a more direct path to success by addressing hunger and satiety at the source

Insurance authorization requirements, prior authorization processes, and formulary placement vary considerably between plans and may favor one formulation over another

Human studies show limited evidence about the medications safety and risks, and animal studies suggest potential harm

Different mechanisms, different goals