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[21] [22] Conversely, symptoms of adrenal insufficiency such as severe fatigue, weight loss, hypotension, or hypoglycemia require urgent assessment, typically starting with morning serum cortisol and possibly ACTH stimulation testing

The psychological impact of persistent pain should not be underestimated, and addressing the cognitive and emotional components of the pain experience can meaningfully improve outcomes

Therefore, in people with diabetes, the early identification of DKD and implementation of effective treatments are imperative to minimise the progression of CKD and its associated comorbidities

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