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Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

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In addition, the trial was conducted according to regulatory standards and comprised four renal impairment groups (including a group with ESRD) with more than ten subjects in each group and included a reference group with normal renal function that was comparable with respect to baseline characteristics [18, 19]

NICE also says tirzepatide can be prescribed in primary care or specialist services if people meet the criteria and NHS Englands commissioning guidance