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For these patients, initiating weight loss injections may be considered if: The potential metabolic benefits (improved diabetes control, cardiovascular risk reduction, weight loss) substantially outweigh gallbladder risks Close monitoring is feasible with regular clinical follow-up Patients understand warning signs of gallbladder complications The rate of weight loss can be moderated through dosing strategies Conversely, patients with symptomatic gallstones experiencing biliary colic (right upper quadrant pain after meals), previous episodes of cholecystitis, or complications such as pancreatitisgenerally should undergo evaluation by a gastroenterologist or surgeon before starting weight loss injections

Inflammation is thought to drive the microangiopathy in lipedema and is perpetuated by elevated M2 macrophages, platelet factor 4, and lymphocytes

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But I just think, oh God, for me as a diabetic, it is something that actually really, really helps me, [and] I sort of feel a bit aggrieved. Prof Kamila Hawthorne, chair of the Royal College of GPs, said semaglutide should not be seen as a miracle drug for weight loss

If they decide not to replace their IUD and do not want to become pregnant, they should alternative methods of birth control