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This dual action, more insulin plus less glucagon, creates a powerful glucose-lowering effect that addresses both sides of the metabolic equation

Patients should maintain open communication with their healthcare team about side effects, as persistent or severe symptoms may require additional intervention or, rarely, treatment discontinuation

A 2023 clinical review found that GLP-1 receptor agonists produced weight loss approximately two to three times greater than bupropion alone, with sustained results when treatment continued

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Protocols vary by institution, so patients should follow their surgical or anesthesia teams instructions