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[DOI] [PubMed] [Google Scholar] 130.Barale C., Buracco S., Cavalot F., Frascaroli C., Guerrasio A., Russo I

More importantly, although AICAR acts on PARP-1 phosphorylation and ABCA1 protein level in the presence or absence of PARP1 treatment, the effects of AICAR could be partially attenuated by PARP-1 treatment

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In the TRIUMPH-1 Phase 3 trial, participants on the 12 mg dose lost an average of 28.3% of their body weight at 80 weeks, and up to 30.3% at 104 weeks in the study extension