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The direct cardiovascular effects of GLP-1 and its analogs remain the focus of this review
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It has also been shown that cold exposure increases plasma glucagon levels, suggesting a role for glucagon in non-shivering thermogenesis [62]
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For people with hyperthyroidism or Graves' disease, GLP-1 use must be discussed carefully with an endocrinologist, as rapid weight loss in the setting of elevated thyroid hormone can increase metabolic stress
