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Description
Implications for employers: This study is consistent with other studies of GLP-1 medications for both diabetes and obesity demonstrating substantial cardiovascular and metabolic benefits of this class of medications
This highlights that there could be more potential opportunities around positive allosteric modulation of the GLP-1 receptor
Goodwin Cartwright, C
Mol Metab 2014;4:118-31.ArticlePubMedPMC 89
Among these, compounds 53 (IC 50 = 4 nM) and 54 (IC 50 = 10 nM) exhibited high DPP-4 inhibitory activities, good efficacy, and selectivity in an oral glucose tolerance test in ICR mice (Figure 7)
