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In large-scale studies, participants using semaglutide or tirzepatide under medical supervision saw average weight loss between 10% and 15% of their body weight over the course of a year

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Insulin resistance in this group of patients results from defects at the molecular level, including impaired insulin receptor-related signaling pathways enhanced by obesity and its features: Excess visceral fat, chronic inflammation, and reactive oxygen species
GLP-1 Analogs Endogenous and exogenous GLP-1 are characterized by a short half-life due to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), an enzyme widely expressed in various cells and commonly found in the bloodstream [50]