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Description
The neuroprotective effects of GLP-1 agonists in rodent models include enhanced cerebral blood flow and minimized oxidative stress and BBB stabilization mechanisms [13]
Neurochem Int

Here, we demonstrate that the effects of cotadutide in reducing body weight and food intake and improving glucose control are predominantly mediated through Glp-1 signalling, whereas its action on the liver to reduce lipid content, drive glycogen flux and improve mitochondrial turnover and function are directly mediated through Gcg signalling

Because SCFA production depends on microbiome and diet, GLP-1 medications alone cannot rebuild this pathway

approved final version of manuscript
