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This 39-amino acid peptide showed structural similarity to human GLP-1, sharing approximately 53% sequence homology

As a GLP-1RA, 102 albiglutide works by stimulating insulin release and reducing glucagon production, leading to improved blood sugar control in patients with T2DM

First-Generation GLP-1RAs: Liraglutide and Semaglutide Liraglutide (Saxenda ) was the first GLP-1RA approved for adolescent obesity

The LEAN trial with liraglutide and a phase 2 trial of semaglutide in patients with non-alcoholic steatohepatitis (NASH) showed improvements in liver histology and reductions in hepatic inflammation markers