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The mean time to intensification of treatment with insulin was 7.1, 6.1 and 6.0 years for those taking one, two or three oral drugs

Anything higher than this signals the need to initiate or alter therapy
This can be attributed to the metabolic adaptations that are seen to occur in those with obesity

Associate Director for Science & Chief Scientific Advisor, ORS, OGD, CDER, FDA Dr
