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In TRIUMPH-1, the pivotal 80-week obesity trial with 2,339 participants, the 12 mg dose produced an average weight loss of 28.3%, and 45.3% of participants on that dose lost 30% or more of their body weight a threshold historically associated with bariatric surgery outcomes

This condition, mainly caused by bacterial infections, oxidative stress, alcohol or chronic allergen exposure, and dysbiosis, leads to the development of several pathologic conditions, including obesity, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver cirrhosis, neurodegeneration, cardiovascular diseases, inflammatory bowel disease, celiac disease, irritable bowel syndrome, type 1 diabetes mellitus (T1D), and several autoimmune conditions (Fig