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GLP-1 RAs further exhibit anti-inflammatory properties that result in reduced concentrations of interleukin-6 and monocyte chemoattractant protein-1, and in the lungs, GLP-1 promotes vasodilation, surfactant production, and bronchodilation via nitric oxide activation [85]

Current Status of Glucagon-like Peptide-1 Receptor Agonists in Metabolic Dysfunction-associated Steatotic Liver Disease: A Clinical Perspective

doi: 10.2174/0113816128375766250720234005

However, although SGLT2is and GLP-1RAs, in particular, are recommended in current guidelines for patients with T2D, especially those at high risk for atherosclerosis, there remains an important gap in their use due to their costs and the low rate of prescription by specialists other than diabetologists (e.g., cardiologists and nephrologists), highlighting the need for specific actions by primary healthcare professionals and specialists and greater efforts to improve discussion and knowledge of these drugs to improve T2D management [3,4,5,6]

Semaglutide-mediated protection against abeta correlated with enhancement of autophagy and inhibition of apotosis